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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 5e6m

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.93
System mass 206.23 kDa
Deposition year 2015
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 5e6m
Reference Qin Xiangjing, Deng Xiangyu, Chen Lei, Xie Wei. 2016. Crystal Structure of the Wild-Type Human GlyRS Bound with tRNAGly in a Productive Conformation Journal of Molecular Biology
Equivalence Class NR_all_06496.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GAP
Residue . / 701
Chain E / A
Non-redundant True
Interacting RNA chains D/E
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains D/E: tRNA
RNA family global tRNA
Volume 560.81 Å3
Hydrophobicity 0.724
Hydrophilicity 1.166
Buriedness 0.831
Don/acc character 0.717
SiteScore 1.089
D Score 1.058
Kd

Compound GAP
Residue . / 701
Chain G / B
Non-redundant True
Interacting RNA chains C/C
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains C/C: tRNA
RNA family global tRNA
Volume 542.63 Å3
Hydrophobicity 0.999
Hydrophilicity 1.000
Buriedness 0.828
Don/acc character 0.511
SiteScore 1.095
D Score 1.111
Kd