Complex 5dto
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.60 |
| System mass | 105.15 kDa |
| Deposition year | 2015 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Orthoflavivirus |
| RCSB PDB Entry | 5dto |
| Reference | Zhao Yongqian, Soh Tingjin Sherryl, Lim Siew Pheng, Chung Ka Yan, Swaminathan Kunchithapadam, Vasudevan Subhash G., Shi Pei-Yong, Lescar Julien, Luo Dahai. 2015. Molecular basis for specific viral RNA recognition and 2′-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5) Proceedings of the National Academy of Sciences |
| Equivalence Class |
NR_all_38685.1
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | SAH |
| Residue | . / 1003 |
| Chain | E / A |
| Non-redundant | True |
| Interacting RNA chains | B/B |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | B/B: unknown |
| RNA family global | unknown |
| Volume | 355.01 Å3 |
| Hydrophobicity | 0.627 |
| Hydrophilicity | 1.245 |
| Buriedness | 0.844 |
| Don/acc character | 0.508 |
| SiteScore | 1.098 |
| D Score | 1.041 |
| Kd | — |