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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 5dm7

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.00
System mass 1360.56 kDa
Deposition year 2015
Molecule type RNA/Protein
# RNA entities 1
Organism Deinococcus
RCSB PDB Entry 5dm7
Reference Kaminishi Tatsuya, Schedlbauer Andreas, Fabbretti Attilio, Brandi Letizia, Ochoa-Lizarralde Borja, He Cheng-Guang, Milón Pohl, Connell Sean R., Gualerzi Claudio O., Fucini Paola. 2015. Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A Nucleic Acids Research
Equivalence Class NR_all_88987.11
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound HGR
Residue . / 6178
Chain DH / X
Non-redundant True
Interacting RNA chains CA/X
RNA environment detailled ion
RNA environment global RNA
RNA family chains CA/X: rRNA
RNA family global rRNA
Volume 372.84 Å3
Hydrophobicity 0.979
Hydrophilicity 0.763
Buriedness 0.764
Don/acc character 1.847
SiteScore 1.218
D Score 1.111
Kd