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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 5dgf

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.30
System mass 6286.47 kDa
Deposition year 2015
Molecule type RNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 5dgf
Equivalence Class NR_all_90506.85
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPS
Residue . / 3401
Chain NF / 1
Non-redundant True
Interacting RNA chains JA/1
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains JA/1: rRNA
RNA family global rRNA
Volume 542.63 Å3
Hydrophobicity 0.413
Hydrophilicity 1.340
Buriedness 0.739
Don/acc character 0.698
SiteScore 0.641
D Score 0.947
Kd

Compound SPS
Residue . / 3401
Chain NG / B
Non-redundant True
Interacting RNA chains KD/5
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains KD/5: rRNA
RNA family global rRNA
Volume 735.05 Å3
Hydrophobicity 0.413
Hydrophilicity 1.323
Buriedness 0.774
Don/acc character 0.975
SiteScore 1.201
D Score 0.973
Kd