Complex 4wtf
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.65 |
| System mass | 69.36 kDa |
| Deposition year | 2014 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 4wtf |
| Reference | Appleby Todd C., Perry Jason K., Murakami Eisuke, Barauskas Ona, Feng Joy, Cho Aesop, Fox David, Wetmore Diana R., McGrath Mary E., Ray Adrian S., Sofia Michael J., Swaminathan S., Edwards Thomas E.. 2015. Structural basis for RNA replication by the hepatitis C virus polymerase Science |
| Equivalence Class |
NR_all_71999.2
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | 5GS |
| Residue | . / 605 |
| Chain | H / A |
| Non-redundant | True |
| Interacting RNA chains | B/P, A/T |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/T: synthetic construct, B/P: synthetic construct |
| RNA family global | synthetic construct |
| Volume | 199.63 Å3 |
| Hydrophobicity | 0.206 |
| Hydrophilicity | 1.338 |
| Buriedness | 0.650 |
| Don/acc character | 0.466 |
| SiteScore | 0.968 |
| D Score | 0.894 |
| Kd | — |