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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4wqy

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.80
System mass 4707.31 kDa
Deposition year 2014
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 4wqy
Reference Lin Jinzhong, Gagnon Matthieu G., Bulkley David, Steitz Thomas A.. 2015. Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation Cell
Equivalence Class NR_all_97519.80
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GDP
Residue . / 801
Chain DWA / BZ
Non-redundant True
Interacting RNA chains A/AA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains A/AA: rRNA
RNA family global rRNA
Volume 178.02 Å3
Hydrophobicity 0.344
Hydrophilicity 0.879
Buriedness 0.662
Don/acc character 0.374
SiteScore 0.655
D Score 0.599
Kd