HARIBOSS logo

HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4wqf

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.80
System mass 4753.18 kDa
Deposition year 2014
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 4wqf
Reference Lin Jinzhong, Gagnon Matthieu G., Bulkley David, Steitz Thomas A.. 2015. Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation Cell
Equivalence Class NR_all_97519.80
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound FUA
Residue . / 703
Chain WVA / BZ
Non-redundant True
Interacting RNA chains A/AA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains A/AA: rRNA
RNA family global rRNA
Volume 287.09 Å3
Hydrophobicity 0.764
Hydrophilicity 0.720
Buriedness 0.710
Don/acc character 1.276
SiteScore 1.055
D Score 1.112
Kd

Compound FUA
Residue . / 703
Chain OEC / DZ
Non-redundant True
Interacting RNA chains GB/CA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains GB/CA: rRNA
RNA family global rRNA
Volume 367.01 Å3
Hydrophobicity 0.558
Hydrophilicity 0.934
Buriedness 0.702
Don/acc character 1.198
SiteScore 1.023
D Score 1.057
Kd