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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4wfn

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.54
System mass 1348.06 kDa
Deposition year 2014
Molecule type RNA/Protein
# RNA entities 1
Organism Deinococcus
RCSB PDB Entry 4wfn
Reference Wekselman Itai, Zimmerman Ella, Davidovich Chen, Belousoff Matthew, Matzov Donna, Krupkin Miri, Rozenberg Haim, Bashan Anat, Friedlander Gilgi, Kjeldgaard Jette, Ingmer Hanne, Lindahl Lasse, Zengel Janice M., Yonath Ada. 2017. The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel Structure
Equivalence Class NR_all_88987.11
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ERY
Residue . / 2902
Chain JA / X
Non-redundant True
Interacting RNA chains AA/X
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains AA/X: rRNA
RNA family global rRNA
Volume 725.79 Å3
Hydrophobicity 0.290
Hydrophilicity 1.090
Buriedness 0.738
Don/acc character 2.109
SiteScore 1.176
D Score 1.027
Kd