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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4v8u

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.70
System mass 4655.34 kDa
Deposition year 2012
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 4v8u
Reference Feng Shu, Chen Yun, Gao Yong-Gui. 2013. Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex PLoS ONE
Equivalence Class NR_all_97519.80
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound FUA
Residue . / 701
Chain MD / AY
Non-redundant True
Interacting RNA chains JA/BA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains JA/BA: rRNA
RNA family global rRNA
Volume 344.37 Å3
Hydrophobicity 0.566
Hydrophilicity 1.030
Buriedness 0.717
Don/acc character 1.206
SiteScore 1.015
D Score 1.035
Kd

Compound FUA
Residue . / 701
Chain TD / CY
Non-redundant True
Interacting RNA chains OC/DA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains OC/DA: rRNA
RNA family global rRNA
Volume 359.81 Å3
Hydrophobicity 0.262
Hydrophilicity 1.274
Buriedness 0.691
Don/acc character 0.824
SiteScore 0.995
D Score 0.939
Kd