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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4v89

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Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.70
System mass 2264.28 kDa
Deposition year 2011
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 4v89
Reference Zhou Jie, Lancaster Laura, Trakhanov Sergei, Noller Harry F.. 2012. Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome RNA
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound GNP
Residue . / 601
Chain GB / AW
Non-redundant True
Interacting RNA chains GA/BA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains GA/BA: rRNA
RNA family global rRNA
Volume 522.73 Å3
Hydrophobicity 0.339
Hydrophilicity 1.559
Buriedness 0.878
Don/acc character 0.732
SiteScore 1.120
D Score 0.958
Kd