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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4v7b

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Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 6.80
System mass 2301.18 kDa
Deposition year 2013
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 4v7b
Reference Ramrath David J. F., Lancaster Laura, Sprink Thiemo, Mielke Thorsten, Loerke Justus, Noller Harry F., Spahn Christian M. T.. 2013. Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation Proceedings of the National Academy of Sciences
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound FUA
Residue . / 801
Chain GB / AY
Non-redundant True
Interacting RNA chains BA/BA
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains BA/BA: rRNA
RNA family global rRNA
Volume 217.12 Å3
Hydrophobicity 0.779
Hydrophilicity 0.715
Buriedness 0.727
Don/acc character 0.536
SiteScore 0.867
D Score 0.868
Kd