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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4v5f

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.60
System mass 4772.30 kDa
Deposition year 2009
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 4v5f
Reference Gao Yong-Gui, Selmer Maria, Dunham Christine M., Weixlbaumer Albert, Kelley Ann C., Ramakrishnan V.. 2009. The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State Science
Equivalence Class NR_all_97519.80
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound FUA
Residue . / 702
Chain XD / AY
Non-redundant True
Interacting RNA chains JA/BA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains JA/BA: rRNA
RNA family global rRNA
Volume 365.64 Å3
Hydrophobicity 0.510
Hydrophilicity 1.043
Buriedness 0.712
Don/acc character 0.618
SiteScore 1.009
D Score 1.027
Kd

Compound FUA
Residue . / 702
Chain EE / CY
Non-redundant True
Interacting RNA chains TC/DA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains TC/DA: rRNA
RNA family global rRNA
Volume 320.02 Å3
Hydrophobicity 0.401
Hydrophilicity 1.245
Buriedness 0.722
Don/acc character 1.268
SiteScore 0.982
D Score 0.924
Kd