Complex 4uy8

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	Electron Microscopy
Experimental resolution	3.80
System mass	1376.26 kDa
Deposition year	2014
Molecule type	RNA/Protein
# RNA entities	1
Organism	Escherichia
RCSB PDB Entry	4uy8
Reference	Bischoff Lukas, Berninghausen Otto, Beckmann Roland. 2014. Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor Cell Reports
Equivalence Class	NR_all_83717.187 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	TRP
Residue	. / 1001
Chain	LA / 7
Non-redundant	True
Interacting RNA chains	J/A
RNA environment detailled	protein, other
RNA environment global	RNA/Other
RNA family chains	J/A: rRNA
RNA family global	rRNA
Volume	747.05 Å³
Hydrophobicity	0.279
Hydrophilicity	1.566
Buriedness	0.815
Don/acc character	0.911
SiteScore	1.228
D Score	0.918
Kd	—

Pocket 2

Compound	TRP
Residue	. / 1002
Chain	MA / 7
Non-redundant	True
Interacting RNA chains	J/A
RNA environment detailled	protein, other
RNA environment global	RNA/Other
RNA family chains	J/A: rRNA
RNA family global	rRNA
Volume	395.48 Å³
Hydrophobicity	0.073
Hydrophilicity	1.442
Buriedness	0.817
Don/acc character	1.025
SiteScore	1.079
D Score	0.960
Kd	—