Complex 4u4o
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 3.60 |
| System mass | 6630.74 kDa |
| Deposition year | 2014 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Saccharomyces |
| RCSB PDB Entry | 4u4o |
| Reference | Garreau de Loubresse Nicolas, Prokhorova Irina, Holtkamp Wolf, Rodnina Marina V., Yusupova Gulnara, Yusupov Marat. 2014. Structural basis for the inhibition of the eukaryotic ribosome Nature |
| Equivalence Class |
NR_all_03510.74
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | GET |
| Residue | . / 2181 |
| Chain | AQ / 2 |
| Non-redundant | True |
| Interacting RNA chains | A/2 |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/2: rRNA |
| RNA family global | rRNA |
| Volume | 66.20 Å3 |
| Hydrophobicity | 0.096 |
| Hydrophilicity | 0.905 |
| Buriedness | 0.547 |
| Don/acc character | 1.834 |
| SiteScore | 0.693 |
| D Score | 0.484 |
| Kd | — |