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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4qvi

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound MES
Residue . / 2204
Chain J / B
Non-redundant True
Interacting RNA chains B/B
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains B/B: rRNA
RNA family global rRNA
Volume 163.27 Å3
Hydrophobicity 0.247
Hydrophilicity 0.900
Buriedness 0.603
Don/acc character 1.551
SiteScore 0.944
D Score 0.790
Kd