Complex 4n48
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.70 |
| System mass | 102.23 kDa |
| Deposition year | 2013 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 4n48 |
| Reference | Smietanski Miroslaw, Werner Maria, Purta Elzbieta, Kaminska Katarzyna H., Stepinski Janusz, Darzynkiewicz Edward, Nowotny Marcin, Bujnicki Janusz M.. 2014. Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation Nature Communications |
| Equivalence Class |
NR_all_98303.3
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | SAM |
| Residue | . / 601 |
| Chain | E / A |
| Non-redundant | True |
| Interacting RNA chains | C/D |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | C/D: mRNA |
| RNA family global | mRNA |
| Volume | 321.05 Å3 |
| Hydrophobicity | 0.665 |
| Hydrophilicity | 1.212 |
| Buriedness | 0.811 |
| Don/acc character | 0.542 |
| SiteScore | 1.075 |
| D Score | 1.031 |
| Kd | — |
| Compound | SAM |
| Residue | . / 601 |
| Chain | F / B |
| Non-redundant | False |
| Interacting RNA chains | D/G |
| RNA environment detailled | protein |
| RNA environment global | RNA/Protein |
| RNA family chains | D/G: mRNA |
| RNA family global | mRNA |
| Volume | 282.98 Å3 |
| Hydrophobicity | 0.923 |
| Hydrophilicity | 1.128 |
| Buriedness | 0.805 |
| Don/acc character | 0.420 |
| SiteScore | 1.072 |
| D Score | 1.055 |
| Kd | — |