Complex 4lx6
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.15 |
| System mass | 22.97 kDa |
| Deposition year | 2013 |
| Molecule type | RNA |
| # RNA entities | 1 |
| Organism | Vibrio |
| RCSB PDB Entry | 4lx6 |
| Reference | Robinson Christopher J., Vincent Helen A., Wu Ming-Cheng, Lowe Phillip T., Dunstan Mark S., Leys David, Micklefield Jason. 2014. Modular Riboswitch Toolsets for Synthetic Genetic Control in Diverse Bacterial Species Journal of the American Chemical Society |
| Equivalence Class |
NR_all_73445.3
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | 29H |
| Residue | . / 601 |
| Chain | B / A |
| Non-redundant | True |
| Interacting RNA chains | A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: riboswitch |
| RNA family global | riboswitch |
| Volume | 171.16 Å3 |
| Hydrophobicity | 0.166 |
| Hydrophilicity | 1.495 |
| Buriedness | 0.803 |
| Don/acc character | 0.791 |
| SiteScore | 1.069 |
| D Score | 0.741 |
| Kd | 95nM |