Complex 4lvv

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	X-ray
Experimental resolution	2.10
System mass	29.80 kDa
Deposition year	2013
Molecule type	RNA
# RNA entities	1
Organism	Streptococcus
RCSB PDB Entry	4lvv
Reference	Trausch Jeremiah J., Batey Robert T.. 2014. A Disconnect between High-Affinity Binding and Efficient Regulation by Antifolates and Purines in the Tetrahydrofolate Riboswitch Chemistry & Biology
Equivalence Class	NR_all_78797.7 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	FFO
Residue	. / 101
Chain	B / A
Non-redundant	False
Interacting RNA chains	A/A
RNA environment detailled	RNA-only
RNA environment global	RNA
RNA family chains	A/A: riboswitch
RNA family global	riboswitch
Volume	94.67 Å³
Hydrophobicity	0.028
Hydrophilicity	0.853
Buriedness	0.591
Don/acc character	1.451
SiteScore	0.769
D Score	0.574
Kd	9.6uM

Pocket 2

Compound	FFO
Residue	. / 102
Chain	C / A
Non-redundant	True
Interacting RNA chains	A/A
RNA environment detailled	RNA-only
RNA environment global	RNA
RNA family chains	A/A: riboswitch
RNA family global	riboswitch
Volume	71.34 Å³
Hydrophobicity	0.196
Hydrophilicity	0.882
Buriedness	0.574
Don/acc character	3.123
SiteScore	0.676
D Score	0.456
Kd	9.6uM