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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 4ki4

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.45
System mass 115.40 kDa
Deposition year 2013
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 4ki4
Reference Clausen Anders R., Murray Michael S., Passer Andrew R., Pedersen Lars C., Kunkel Thomas A.. 2013. Structure–function analysis of ribonucleotide bypass by B family DNA replicases Proceedings of the National Academy of Sciences

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound TTP
Residue . / 1001
Chain D / A
Non-redundant True
Interacting RNA chains B/T
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains B/T: RNA/DNA_hybrid
RNA family global RNA/DNA_hybrid
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd