Complex 4f8v

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	X-ray
Experimental resolution	2.80
System mass	14.38 kDa
Deposition year	2012
Molecule type	RNA
# RNA entities	1
Organism	N/A
RCSB PDB Entry	4f8v
Reference	Kondo Jiro, Koganei Mai, Kasahara Tomoko. 2012. Crystal Structure and Specific Binding Mode of Sisomicin to the Bacterial Ribosomal Decoding Site ACS Medicinal Chemistry Letters
Equivalence Class	NR_all_71199.7 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	SIS
Residue	. / 101
Chain	C / A
Non-redundant	False
Interacting RNA chains	A/A, B/B
RNA environment detailled	RNA-only
RNA environment global	RNA
RNA family chains	A/A: rRNA, B/B: rRNA
RNA family global	rRNA
Volume	-
Hydrophobicity	-
Hydrophilicity	-
Buriedness	-
Don/acc character	-
SiteScore	-
D Score	-
Kd	—

Pocket 2

Compound	SIS
Residue	. / 101
Chain	D / B
Non-redundant	False
Interacting RNA chains	A/A, B/B
RNA environment detailled	RNA-only
RNA environment global	RNA
RNA family chains	A/A: rRNA, B/B: rRNA
RNA family global	rRNA
Volume	61.74 Å³
Hydrophobicity	0.143
Hydrophilicity	0.934
Buriedness	0.564
Don/acc character	4.093
SiteScore	0.756
D Score	0.557
Kd	—