Complex 3wru
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.30 |
| System mass | 16.12 kDa |
| Deposition year | 2014 |
| Molecule type | RNA |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 3wru |
| Reference | Maianti Juan Pablo, Kanazawa Hiroki, Dozzo Paola, Matias Rowena D., Feeney Lee Ann, Armstrong Eliana S., Hildebrandt Darin J., Kane Timothy R., Gliedt Micah J., Goldblum Adam A., Linsell Martin S., Aggen James B., Kondo Jiro, Hanessian Stephen. 2014. Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs ACS Chemical Biology |
| Equivalence Class |
NR_all_71199.7
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | SJP |
| Residue | . / 101 |
| Chain | C / A |
| Non-redundant | True |
| Interacting RNA chains | A/A, B/B |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA, B/B: rRNA |
| RNA family global | rRNA |
| Volume | 127.60 Å3 |
| Hydrophobicity | 0.166 |
| Hydrophilicity | 0.792 |
| Buriedness | 0.550 |
| Don/acc character | 2.968 |
| SiteScore | 0.884 |
| D Score | 0.736 |
| Kd | — |
| Compound | SJP |
| Residue | . / 101 |
| Chain | D / B |
| Non-redundant | True |
| Interacting RNA chains | A/A, B/B |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA, B/B: rRNA |
| RNA family global | rRNA |
| Volume | 99.13 Å3 |
| Hydrophobicity | 0.162 |
| Hydrophilicity | 0.908 |
| Buriedness | 0.577 |
| Don/acc character | 2.702 |
| SiteScore | 0.777 |
| D Score | 0.582 |
| Kd | — |