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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 3jbv

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 3.32
System mass 2199.60 kDa
Deposition year 2015
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 3jbv
Reference Zhang Jun, Pan Xijiang, Yan Kaige, Sun Shan, Gao Ning, Sui Sen-Fang. 2015. Mechanisms of ribosome stalling by SecM at multiple elongation steps eLife
Equivalence Class NR_all_83717.187
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CLM
Residue . / 9000
Chain EB / b
Non-redundant True
Interacting RNA chains HA/b
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains HA/b: rRNA
RNA family global rRNA
Volume 522.73 Å3
Hydrophobicity 0.204
Hydrophilicity 1.384
Buriedness 0.825
Don/acc character 1.325
SiteScore 1.235
D Score 0.984
Kd