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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 3jb7

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 4.00
System mass 213.00 kDa
Deposition year 2015
Molecule type RNA/Protein
# RNA entities 1
Organism Cypovirus
RCSB PDB Entry 3jb7
Reference Zhang Xing, Ding Ke, Yu Xuekui, Chang Winston, Sun Jingchen, Hong Zhou Z.. 2015. In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus Nature
Equivalence Class NR_all_37313.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CTP
Residue . / 1302
Chain H / A
Non-redundant False
Interacting RNA chains E/m, D/t
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains D/t: unknown, E/m: unknown
RNA family global unknown
Volume 673.31 Å3
Hydrophobicity 0.432
Hydrophilicity 1.519
Buriedness 0.863
Don/acc character 0.736
SiteScore 1.111
D Score 0.963
Kd