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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 3bsn

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 1.80
System mass 63.37 kDa
Deposition year 2007
Molecule type RNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 3bsn
Reference Zamyatkin Dmitry F., Parra Francisco, Alonso José M. Martín, Harki Daniel A., Peterson Blake R., Grochulski Pawel, Ng Kenneth K.-S.. 2008. Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase Journal of Biological Chemistry
Equivalence Class NR_all_64844.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound N5C
Residue . / 514
Chain I / A
Non-redundant False
Interacting RNA chains C/T, B/P
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains B/P: unknown, C/T: unknown
RNA family global unknown
Volume 686.69 Å3
Hydrophobicity 0.371
Hydrophilicity 1.592
Buriedness 0.862
Don/acc character 0.765
SiteScore 1.109
D Score 0.938
Kd