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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 30es

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.54
System mass 522.13 kDa
Deposition year 2026
Molecule type RNA/DNA/Protein
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 30es
Reference Yi Gangshun, Li Qingrong, Holmberg Hannah, Li Shisheng, Clare Daniel K., Wang Dong, Zhang Peijun. 2026. Structural Dynamics of RNA Polymerase II During Nucleotide Addition Cycle preprint (openRxiv)

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ATP
Residue . / 1801
Chain N / A
Non-redundant True
Interacting RNA chains L/R
RNA environment detailled DNA, protein, ion
RNA environment global RNA/DNA/Protein
RNA family chains L/R: unknown
RNA family global unknown
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd