Complex 2pwt
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 1.80 |
| System mass | 16.08 kDa |
| Deposition year | 2007 |
| Molecule type | RNA |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 2pwt |
| Reference | Kondo Jiro, Pachamuthu Kandasamy, François Boris, Szychowski Janek, Hanessian Stephen, Westhof Eric. 2007. Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A‐Minor Motif Enhances in vitro Antibacterial Activity ChemMedChem |
| Equivalence Class |
NR_all_71199.7
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | LHA |
| Residue | . / 51 |
| Chain | C / A |
| Non-redundant | True |
| Interacting RNA chains | B/B, A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA, B/B: rRNA |
| RNA family global | rRNA |
| Volume | 76.15 Å3 |
| Hydrophobicity | 0.079 |
| Hydrophilicity | 0.939 |
| Buriedness | 0.553 |
| Don/acc character | 3.464 |
| SiteScore | 0.859 |
| D Score | 0.590 |
| Kd | — |
| Compound | LHA |
| Residue | . / 50 |
| Chain | D / B |
| Non-redundant | True |
| Interacting RNA chains | B/B, A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA, B/B: rRNA |
| RNA family global | rRNA |
| Volume | - |
| Hydrophobicity | - |
| Hydrophilicity | - |
| Buriedness | - |
| Don/acc character | - |
| SiteScore | - |
| D Score | - |
| Kd | — |
| Compound | LHA |
| Residue | . / 55 |
| Chain | E / B |
| Non-redundant | True |
| Interacting RNA chains | B/B, A/A |
| RNA environment detailled | RNA-only |
| RNA environment global | RNA |
| RNA family chains | A/A: rRNA, B/B: rRNA |
| RNA family global | rRNA |
| Volume | 37.39 Å3 |
| Hydrophobicity | 0.031 |
| Hydrophilicity | 0.446 |
| Buriedness | 0.312 |
| Don/acc character | 2.920 |
| SiteScore | 0.807 |
| D Score | 0.726 |
| Kd | — |