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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 2oe5

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 1.51
System mass 11.24 kDa
Deposition year 2006
Molecule type RNA
# RNA entities 1
Organism N/A
RCSB PDB Entry 2oe5
Reference Hermann Thomas, Tereshko Valentina, Skripkin Eugene, Patel Dinshaw J.. 2007. Apramycin recognition by the human ribosomal decoding site Blood Cells, Molecules, and Diseases
Equivalence Class NR_all_73746.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound AM2
Residue . / 101
Chain E / B
Non-redundant True
Interacting RNA chains B/B, A/A
RNA environment detailled ion
RNA environment global RNA
RNA family chains A/A: rRNA, B/B: rRNA
RNA family global rRNA
Volume 458.25 Å3
Hydrophobicity 0.097
Hydrophilicity 0.941
Buriedness 0.666
Don/acc character 1.504
SiteScore 1.028
D Score 0.880
Kd