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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 2o3y

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.70
System mass 14.91 kDa
Deposition year 2006
Molecule type RNA
# RNA entities 1
Organism N/A
RCSB PDB Entry 2o3y
Reference Kondo Jiro, Hainrichson Mariana, Nudelman Igor, Shallom‐Shezifi Dalia, Barbieri Christopher M., Pilch Daniel S., Westhof Eric, Baasov Timor. 2007. Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites ChemBioChem
Equivalence Class NR_all_54657.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 51
Chain C / A
Non-redundant True
Interacting RNA chains A/A, B/B
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA, B/B: rRNA
RNA family global rRNA
Volume 99.81 Å3
Hydrophobicity 0.050
Hydrophilicity 0.765
Buriedness 0.648
Don/acc character 1.892
SiteScore 0.721
D Score 0.504
Kd