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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 2m4q

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Solution NMR
Experimental resolution N/A
System mass 9.20 kDa
Deposition year 2013
Molecule type RNA
# RNA entities 1
Organism N/A
RCSB PDB Entry 2m4q
Reference Tsai Albert, Uemura Sotaro, Johansson Magnus, Puglisi Elisabetta Viani, Marshall R. Andrew, Aitken Colin Echeverría, Korlach Jonas, Ehrenberg Måns, Puglisi Joseph D.. 2013. The Impact of Aminoglycosides on the Dynamics of Translation Elongation Cell Reports
Equivalence Class NR_all_04218.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound AM2
Residue . / 101
Chain B / 1
Non-redundant True
Interacting RNA chains A/1
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/1: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd