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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 2hvy

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.30
System mass 94.92 kDa
Deposition year 2006
Molecule type RNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 2hvy
Reference Li Ling, Ye Keqiong. 2006. Crystal structure of an H/ACA box ribonucleoprotein particle Nature
Equivalence Class NR_all_99751.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ATP
Residue . / 501
Chain F / A
Non-redundant True
Interacting RNA chains A/E
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/E: unknown
RNA family global unknown
Volume 60.03 Å3
Hydrophobicity 0.239
Hydrophilicity 0.536
Buriedness 0.505
Don/acc character 3.015
SiteScore 0.748
D Score 0.786
Kd