Complex 2fcz
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.01 |
| System mass | 31.84 kDa |
| Deposition year | 2005 |
| Molecule type | RNA |
| # RNA entities | 1 |
| Organism | N/A |
| RCSB PDB Entry | 2fcz |
| Reference | Ennifar E.. 2006. Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell Nucleic Acids Research |
| Equivalence Class |
NR_all_78706.4
BGSU version: 4.52 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | RIO |
| Residue | . / 1024 |
| Chain | F / A |
| Non-redundant | True |
| Interacting RNA chains | B/B, A/A |
| RNA environment detailled | ion, other |
| RNA environment global | RNA/Other |
| RNA family chains | A/A: TAR_rna, B/B: TAR_rna |
| RNA family global | TAR_rna |
| Volume | 589.96 Å3 |
| Hydrophobicity | 0.153 |
| Hydrophilicity | 1.092 |
| Buriedness | 0.684 |
| Don/acc character | 1.337 |
| SiteScore | 1.140 |
| D Score | 0.994 |
| Kd | — |
| Compound | RIO |
| Residue | . / 2024 |
| Chain | H / B |
| Non-redundant | False |
| Interacting RNA chains | B/B, A/A |
| RNA environment detailled | ion, other |
| RNA environment global | RNA/Other |
| RNA family chains | A/A: TAR_rna, B/B: TAR_rna |
| RNA family global | TAR_rna |
| Volume | 488.43 Å3 |
| Hydrophobicity | 0.173 |
| Hydrophilicity | 1.216 |
| Buriedness | 0.680 |
| Don/acc character | 0.956 |
| SiteScore | 1.138 |
| D Score | 0.952 |
| Kd | — |
| Compound | RIO |
| Residue | . / 3024 |
| Chain | J / C |
| Non-redundant | False |
| Interacting RNA chains | D/D, C/C |
| RNA environment detailled | ion, other |
| RNA environment global | RNA/Other |
| RNA family chains | C/C: TAR_rna, D/D: TAR_rna |
| RNA family global | TAR_rna |
| Volume | 546.40 Å3 |
| Hydrophobicity | 0.215 |
| Hydrophilicity | 1.035 |
| Buriedness | 0.679 |
| Don/acc character | 1.375 |
| SiteScore | 1.138 |
| D Score | 1.010 |
| Kd | — |
| Compound | RIO |
| Residue | . / 4024 |
| Chain | L / D |
| Non-redundant | False |
| Interacting RNA chains | D/D, C/C |
| RNA environment detailled | ion, other |
| RNA environment global | RNA/Other |
| RNA family chains | C/C: TAR_rna, D/D: TAR_rna |
| RNA family global | TAR_rna |
| Volume | 512.10 Å3 |
| Hydrophobicity | 0.178 |
| Hydrophilicity | 1.248 |
| Buriedness | 0.707 |
| Don/acc character | 0.989 |
| SiteScore | 1.156 |
| D Score | 0.957 |
| Kd | — |