Complex 2fcx

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	X-ray
Experimental resolution	2.00
System mass	15.73 kDa
Deposition year	2005
Molecule type	RNA
# RNA entities	1
Organism	N/A
RCSB PDB Entry	2fcx
Reference	Ennifar E.. 2006. Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell Nucleic Acids Research
Equivalence Class	NR_all_78706.4 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	XXX
Residue	. / 101
Chain	F / A
Non-redundant	True
Interacting RNA chains	B/B, A/A
RNA environment detailled	ion, other
RNA environment global	RNA/Other
RNA family chains	A/A: TAR_rna, B/B: TAR_rna
RNA family global	TAR_rna
Volume	545.71 Å³
Hydrophobicity	0.254
Hydrophilicity	1.108
Buriedness	0.683
Don/acc character	1.424
SiteScore	1.140
D Score	0.989
Kd	—

Pocket 2

Compound	XXX
Residue	. / 201
Chain	H / B
Non-redundant	False
Interacting RNA chains	B/B, A/A
RNA environment detailled	other
RNA environment global	RNA/Other
RNA family chains	A/A: TAR_rna, B/B: TAR_rna
RNA family global	TAR_rna
Volume	486.37 Å³
Hydrophobicity	0.129
Hydrophilicity	1.150
Buriedness	0.681
Don/acc character	1.408
SiteScore	1.138
D Score	0.974
Kd	—