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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 2e9z

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.00
System mass 59.28 kDa
Deposition year 2007
Molecule type RNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 2e9z
Reference Ferrer-Orta Cristina, Arias Armando, Pérez-Luque Rosa, Escarmís Cristina, Domingo Esteban, Verdaguer Nuria. 2007. Sequential structures provide insights into the fidelity of RNA replication Proceedings of the National Academy of Sciences
Equivalence Class NR_all_62003.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound UTP
Residue . / 993
Chain F / A
Non-redundant True
Interacting RNA chains B/C, A/B
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains A/B: unknown, B/C: unknown
RNA family global unknown
Volume 652.73 Å3
Hydrophobicity 0.508
Hydrophilicity 1.236
Buriedness 0.808
Don/acc character 0.690
SiteScore 1.073
D Score 1.021
Kd