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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 2dxi

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.20
System mass 157.52 kDa
Deposition year 2006
Molecule type RNA/Protein
# RNA entities 1
Organism Thermus
RCSB PDB Entry 2dxi
Reference Sekine Shun-ichi, Shichiri Mika, Bernier Stéphane, Chênevert Robert, Lapointe Jacques, Yokoyama Shigeyuki. 2006. Structural Bases of Transfer RNA-Dependent Amino Acid Recognition and Activation by Glutamyl-tRNA Synthetase Structure
Equivalence Class NR_all_29085.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ATP
Residue . / 601
Chain G / A
Non-redundant True
Interacting RNA chains A/C
RNA environment detailled protein, other
RNA environment global RNA/Other
RNA family chains A/C: tRNA
RNA family global tRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd