Complex 2be0

Legend

Pocket colors by molecule type

RNA

Protein

DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique	X-ray
Experimental resolution	2.63
System mass	15.61 kDa
Deposition year	2005
Molecule type	RNA
# RNA entities	1
Organism	Streptomyces
RCSB PDB Entry	2be0
Reference	François Boris, Szychowski Janek, Adhikari Susanta Sekhar, Pachamuthu Kandasamy, Swayze Eric E., Griffey Richard H., Migawa Michael T., Westhof Eric, Hanessian Stephen. 2004. Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal‐RNA Decoding Site Angewandte Chemie International Edition
Equivalence Class	NR_all_71199.7 BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

Favourable

Intermediate

Unfavourable

Not available

Score	Threshold	Meaning
SiteScore	< 0.8	Non-drug binding site
SiteScore	0.8 – 1.0	Potential drug binding site
SiteScore	> 1.0	Promising binding site
D Score	< 0.83	Undruggable
D Score	0.83 – 0.98	Difficult
D Score	> 0.98	Druggable

Tick a pocket below to highlight it in the 3D structure above.

Pocket 1

Compound	JS5
Residue	. / 50
Chain	C / A
Non-redundant	True
Interacting RNA chains	B/B, A/A
RNA environment detailled	RNA-only
RNA environment global	RNA
RNA family chains	A/A: rRNA, B/B: rRNA
RNA family global	rRNA
Volume	375.59 Å³
Hydrophobicity	0.140
Hydrophilicity	0.973
Buriedness	0.636
Don/acc character	1.775
SiteScore	1.080
D Score	0.951
Kd	0.13uM

Pocket 2

Compound	JS5
Residue	. / 51
Chain	D / B
Non-redundant	True
Interacting RNA chains	B/B, A/A
RNA environment detailled	RNA-only
RNA environment global	RNA
RNA family chains	A/A: rRNA, B/B: rRNA
RNA family global	rRNA
Volume	367.01 Å³
Hydrophobicity	0.123
Hydrophilicity	1.029
Buriedness	0.629
Don/acc character	1.587
SiteScore	1.084
D Score	0.953
Kd	0.13uM