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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 29ix

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 2.20
System mass 2564.25 kDa
Deposition year 2026
Molecule type RNA/Protein
# RNA entities 1
Organism Homo
RCSB PDB Entry 29ix
Reference Schwaller Nino, Andenmatten Dominic, Luginbühl Jonas, Rabl Julius, Baur Helena, Chambon Marc, Vesin Jonathan, Turcatti Gerardo, Karousis Evangelos D.. 2026. A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal inhibitor that binds the peptidyl transferase center Communications Biology
Equivalence Class NR_all_65061.67
BGSU version: 4.61

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound A1JQ4
Residue . / 5324
Chain XJ / DA
Non-redundant True
Interacting RNA chains OA/DA
RNA environment detailled ion
RNA environment global RNA
RNA family chains OA/DA: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd —

Compound ATP
Residue . / 5112
Chain TB / DA
Non-redundant True
Interacting RNA chains OA/DA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains OA/DA: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd —

Compound SPM
Residue . / 5108
Chain PB / DA
Non-redundant True
Interacting RNA chains OA/DA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains OA/DA: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd —

Compound SPM
Residue . / 5109
Chain QB / DA
Non-redundant True
Interacting RNA chains OA/DA
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains OA/DA: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd —

Compound SPM
Residue . / 5110
Chain RB / DA
Non-redundant True
Interacting RNA chains OA/DA
RNA environment detailled protein, ion, other
RNA environment global RNA/Other
RNA family chains OA/DA: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd —

Compound SPM
Residue . / 5111
Chain SB / DA
Non-redundant True
Interacting RNA chains OA/DA
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains OA/DA: rRNA
RNA family global rRNA
Volume -
Hydrophobicity -
Hydrophilicity -
Buriedness -
Don/acc character -
SiteScore -
D Score -
Kd —