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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 23ka

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.59
System mass 34.75 kDa
Deposition year 2026
Molecule type RNA
# RNA entities 1
Organism N/A
RCSB PDB Entry 23ka
Reference Tsuzuki Kosuke, Onizuka Kazumitsu, Okada Momo, Nagasawa Ryosuke, Miyashita Emi, Komatsu Kaoru R., Saito Hirohide, Kondo Jiro, Nagatsugi Fumi. 2026. RNA-binding landscape of amiloride: large-scale profiling and structural basis of U–U mismatch recognition RSC Chemical Biology
Equivalence Class NR_all_78542.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound AMR
Residue . / 101
Chain F / B
Non-redundant True
Interacting RNA chains B/B
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains B/B: synthetic construct
RNA family global synthetic construct
Volume 67.91 Å3
Hydrophobicity 0.888
Hydrophilicity 0.943
Buriedness 0.660
Don/acc character 0.681
SiteScore 0.694
D Score 0.453
Kd

Compound AMR
Residue . / 101
Chain I / C
Non-redundant False
Interacting RNA chains C/C
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains C/C: synthetic construct
RNA family global synthetic construct
Volume 127.60 Å3
Hydrophobicity 0.415
Hydrophilicity 0.671
Buriedness 0.559
Don/acc character 3.439
SiteScore 0.803
D Score 0.640
Kd