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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1vfg

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.80
System mass 140.76 kDa
Deposition year 2004
Molecule type RNA/Protein
# RNA entities 1
Organism Thermotoga
RCSB PDB Entry 1vfg
Reference Tomita Kozo, Fukai Shuya, Ishitani Ryuichiro, Ueda Takuya, Takeuchi Nono, Vassylyev Dmitry G., Nureki Osamu. 2004. Structural basis for template-independent RNA polymerization Nature
Equivalence Class NR_all_89906.4
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound APC
Residue . / 1500
Chain F / B
Non-redundant True
Interacting RNA chains B/D
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains B/D: tRNA
RNA family global tRNA
Volume 503.87 Å3
Hydrophobicity 0.674
Hydrophilicity 1.350
Buriedness 0.847
Don/acc character 0.505
SiteScore 1.100
D Score 1.008
Kd