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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1uon

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique Electron Microscopy
Experimental resolution 7.60
System mass 148.08 kDa
Deposition year 2003
Molecule type RNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 1uon
Reference Zhang Xing, Walker Stephen B, Chipman Paul R, Nibert Max L, Baker Timothy S. 2003. Reovirus polymerase λ3 localized by cryo-electron microscopy of virions at a resolution of 7.6 Å Nature Structural & Molecular Biology
Equivalence Class NR_all_06358.1
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound CH1
Residue . / 1301
Chain D / A
Non-redundant True
Interacting RNA chains B/B, C/C
RNA environment detailled protein, ion
RNA environment global RNA/Protein
RNA family chains B/B: synthetic construct, C/C: synthetic construct
RNA family global synthetic construct
Volume 749.11 Å3
Hydrophobicity 0.450
Hydrophilicity 1.463
Buriedness 0.854
Don/acc character 0.548
SiteScore 1.104
D Score 0.975
Kd