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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1tn1

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Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.00
System mass 25.84 kDa
Deposition year 1986
Molecule type RNA
# RNA entities 1
Organism Saccharomyces
RCSB PDB Entry 1tn1
Reference Brown R. S., Dewan J. C., Klug A.. 1985. Crystallographic and biochemical investigation of the lead(II)-catalyzed hydrolysis of yeast phenylalanine tRNA Biochemistry
Equivalence Class NR_all_83593.11
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound SPM
Residue . / 77
Chain B / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled ion
RNA environment global RNA
RNA family chains A/A: tRNA
RNA family global tRNA
Volume 331.00 Å3
Hydrophobicity 0.126
Hydrophilicity 1.501
Buriedness 0.756
Don/acc character 0.970
SiteScore 0.957
D Score 0.800
Kd