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HARIBOSS

Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1sm1

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.42
System mass 1390.06 kDa
Deposition year 2004
Molecule type RNA/Protein
# RNA entities 1
Organism Deinococcus
RCSB PDB Entry 1sm1
Reference Harms Jörg M, Schlünzen Frank, Fucini Paola, Bartels Heike, Yonath Ada. 2004. Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin BMC Biology
Equivalence Class NR_all_88987.11
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound DOL
Residue . / 2882
Chain GA / 0
Non-redundant True
Interacting RNA chains A/0
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/0: rRNA
RNA family global rRNA
Volume 681.54 Å3
Hydrophobicity 0.425
Hydrophilicity 1.155
Buriedness 0.833
Don/acc character 1.619
SiteScore 0.792
D Score 1.063
Kd