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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1ond

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.40
System mass 956.22 kDa
Deposition year 2003
Molecule type RNA/Protein
# RNA entities 1
Organism Deinococcus
RCSB PDB Entry 1ond
Reference Berisio Rita, Schluenzen Frank, Harms Joerg, Bashan Anat, Auerbach Tamar, Baram David, Yonath Ada. 2003. Structural insight into the role of the ribosomal tunnel in cellular regulation Nature Structural & Molecular Biology
Equivalence Class NR_all_88987.11
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound TAO
Residue . / 2881
Chain D / 0
Non-redundant True
Interacting RNA chains A/0
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/0: rRNA
RNA family global rRNA
Volume 487.40 Å3
Hydrophobicity 0.356
Hydrophilicity 1.098
Buriedness 0.683
Don/acc character 1.293
SiteScore 1.140
D Score 0.992
Kd