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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1jzy

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 3.50
System mass 978.50 kDa
Deposition year 2001
Molecule type RNA/Protein
# RNA entities 1
Organism Deinococcus
RCSB PDB Entry 1jzy
Reference Schlünzen Frank, Zarivach Raz, Harms Jörg, Bashan Anat, Tocilj Ante, Albrecht Renate, Yonath Ada, Franceschi François. 2001. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria Nature
Equivalence Class NR_all_88987.11
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound ERY
Residue . / 2881
Chain E / A
Non-redundant True
Interacting RNA chains A/A
RNA environment detailled RNA-only
RNA environment global RNA
RNA family chains A/A: rRNA
RNA family global rRNA
Volume 622.55 Å3
Hydrophobicity 0.025
Hydrophilicity 1.792
Buriedness 0.775
Don/acc character 1.549
SiteScore 1.201
D Score 0.821
Kd