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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1i5l

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.75
System mass 120.21 kDa
Deposition year 2001
Molecule type RNA/Protein
# RNA entities 1
Organism N/A
RCSB PDB Entry 1i5l
Reference Törö Imre, Thore Stéphane, Mayer Claudine, Basquin Jérôme, Séraphin Bertrand, Suck Dietrich. 2001. RNA binding in an Sm core domain: X‐ray structure and functional analysis of an archaeal Sm protein complex The EMBO Journal
Equivalence Class NR_all_92489.7
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound URI
Residue . / 201
Chain Q / A
Non-redundant True
Interacting RNA chains A/U
RNA environment detailled protein, other
RNA environment global RNA/Other
RNA family chains A/U: unknown
RNA family global unknown
Volume 168.41 Å3
Hydrophobicity 0.330
Hydrophilicity 1.296
Buriedness 0.774
Don/acc character 0.588
SiteScore 0.922
D Score 0.817
Kd