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Harnessing RIBOnucleic acid - Small molecules Structures

Illustration - complex

Complex 1c0a

Legend

Pocket colors by molecule type

 RNA

 Protein

 DNA

These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).

System information

Experimental technique X-ray
Experimental resolution 2.40
System mass 91.34 kDa
Deposition year 1999
Molecule type RNA/Protein
# RNA entities 1
Organism Escherichia
RCSB PDB Entry 1c0a
Reference Eiler S., Dock‐Bregeon A.‐C., Moulinier L., Thierry J.‐C., Moras D.. 1999. Synthesis of aspartyl‐tRNAAsp in Escherichia coli—a snapshot of the second step The EMBO Journal
Equivalence Class NR_all_56204.3
BGSU version: 4.52

Pockets List

Legend

Cell colors for SiteScore and D Score:

 Favourable

 Intermediate

 Unfavourable

 Not available

ScoreThresholdMeaning
SiteScore< 0.8Non-drug binding site
SiteScore0.8 – 1.0Potential drug binding site
SiteScore> 1.0Promising binding site
D Score< 0.83Undruggable
D Score0.83 – 0.98Difficult
D Score> 0.98Druggable

Tick a pocket below to highlight it in the 3D structure above.

Compound AMO
Residue . / 831
Chain E / A
Non-redundant True
Interacting RNA chains A/B
RNA environment detailled protein
RNA environment global RNA/Protein
RNA family chains A/B: tRNA
RNA family global tRNA
Volume 664.73 Å3
Hydrophobicity 0.683
Hydrophilicity 1.287
Buriedness 0.841
Don/acc character 0.841
SiteScore 1.095
D Score 1.025
Kd