Complex 12dp
Legend
Pocket colors by molecule type
RNA
Protein
DNA
These colors appear when a pocket is selected (the structure fades to show the pocket surface). Colors from the molecule-type palette (RNA / protein / DNA).
System information
| Experimental technique | X-ray |
| Experimental resolution | 2.95 |
| System mass | 4470.84 kDa |
| Deposition year | 2026 |
| Molecule type | RNA/Protein |
| # RNA entities | 1 |
| Organism | Thermus |
| RCSB PDB Entry | 12dp |
| Reference | Paranjpe Madhura N, Leroy Elodie C, Syroegin Egor A, Flemmich Laurin, Thaler Julia, Gillard Mélanie, Bougas Anthony, Kournoutou Georgia, Dinos George P, Renault Thibaud T, Micura Ronald, Innis C Axel, Polikanov Yury S. 2026. Sparsomycin inhibits translation through a conserved mechanism across all domains of life Nucleic Acids Research |
| Equivalence Class |
NR_all_35542.170,
NR_all_97519.81
BGSU version: 4.56 |
Pockets List
Legend
Cell colors for SiteScore and D Score:
Favourable
Intermediate
Unfavourable
Not available
| Score | Threshold | Meaning |
|---|---|---|
| SiteScore | < 0.8 | Non-drug binding site |
| SiteScore | 0.8 – 1.0 | Potential drug binding site |
| SiteScore | > 1.0 | Promising binding site |
| D Score | < 0.83 | Undruggable |
| D Score | 0.83 – 0.98 | Difficult |
| D Score | > 0.98 | Druggable |
Tick a pocket below to highlight it in the 3D structure above.
| Compound | SPS |
| Residue | . / 4105 |
| Chain | QTA / 1A |
| Non-redundant | True |
| Interacting RNA chains | BB/1x, A/1A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | A/1A: rRNA, BB/1x: tRNA |
| RNA family global | multiple |
| Volume | - |
| Hydrophobicity | - |
| Hydrophilicity | - |
| Buriedness | - |
| Don/acc character | - |
| SiteScore | - |
| D Score | - |
| Kd | — |
| Compound | SPS |
| Residue | . / 3851 |
| Chain | FRC / 2A |
| Non-redundant | True |
| Interacting RNA chains | DD/2x, CB/2A |
| RNA environment detailled | protein, ion |
| RNA environment global | RNA/Protein |
| RNA family chains | CB/2A: rRNA, DD/2x: tRNA |
| RNA family global | multiple |
| Volume | - |
| Hydrophobicity | - |
| Hydrophilicity | - |
| Buriedness | - |
| Don/acc character | - |
| SiteScore | - |
| D Score | - |
| Kd | — |